Prognostic significance of sPD-1/sPD-L1 in renal cancer depending on the phenotype of tumor and stromal cells

Background. The search for new prognostic markers of renal cell carcinoma is an urgent problem oncourology. Modern studies demonstrate the need a comprehensive assessment clinical and significance many markers. Aim analysis soluble forms PD-1 PD-L1 (sPD-1 sPD-L1) depending on phenotype tumor cells microenvironment. Materials methods . study included tissue serum samples from 54 patients with cancer 67 healthy donors. concentrations sPD-1 sPD-L1 were determined in blood using ELISA. Tissue expression PD-L1, PU.1, CD3, CD20 was assessed by immunohistochemistry. To determine statistically significant differences independent groups, Mann–Whitney test Fisher’s exact used. Overall survival analyzed constructing curves Kaplan–Meier method. Differences considered at p <0.05. Results. Increase concentration compared donors demonstrated. highest form receptor observed non-clear carcinoma. High levels are associated disease progression (advanced stage, higher malignancy, as well presence regional metastases). It has been shown that high content PU.1+ CD20+ stroma factors unfavorable prognosis. No found both expressed tissue. However, combination these showed together extremely factor. Conclusion. Analysis approach assessing prognosis